31SY

Human wild-type LONP1 bound to PZL-26

This is a non-PDB format compatible entry.

Summary for 31SY

• Entry DOI: 10.2210/pdb31sy/pdb
• EMDB information: 58651
• Descriptor: Lon protease homolog, mitochondrial, [(1~{R})-1-[[(2~{R})-4-morpholin-4-yl-4-oxidanylidene-2-(pyrazin-2-ylcarbonylamino)butanoyl]amino]-4-phenyl-butyl]boronic acid (2 entities in total)
• Functional Keywords: inhibitor, aaa+ protease, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 600218.47

Authors

Pardo-Hernandez, C.,Green, J.,Gustafsson, C.M. (deposition date: 2026-06-23, release date: 2026-09-30)

• Primary citation: Szilagyi, Z.,Michon, P.,Pardo-Hernandez, C.,Sacultanu, M.,Miralles Fuste, J.,Griffin, A.M.,Charifson, P.S.,Phan, C.,Shi, Y.,Kern, G.,Martinez Botella, G.,Keating, T.A.,Macao, B.,Larsson, N.G.,Falkenberg, M.,Green, J.,Gustafsson, C.M.; A selective inhibitor reveals roles for LONP1 in mitochondrial proteostasis and OXPHOS dependencies; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3 Å)