31EL

NSP14 IN COMPLEX WITH LIGAND MAVDA-K-197

This is a non-PDB format compatible entry.

Summary for 31EL

• Entry DOI: 10.2210/pdb31el/pdb
• Descriptor: Guanine-N7 methyltransferase nsp14, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (6 entities in total)
• Functional Keywords: nsp14, sars-cov-2, methyltransferase, viral protein, inhibitor complex
• Biological source: SARS-CoV-2 pseudovirus
• Total number of polymer chains: 2
• Total formula weight: 122257.23

Authors

Meyer, C.,Ganichkin, O.,Nitsche, J.,Steinbacher, S.,Tuschl, T. (deposition date: 2026-05-29, release date: 2026-09-09)

• Primary citation: Meyer, C.,Garzia, A.,Merritt, J.,Freundlich, J.S.,Hoffmann, H.,Ashbrook, A.W.,Zimmerman, M.,Nelson, A.M.,Davis, J.A.,Balkovec, J.,Murugan, M.,Chang, C.,Oswal, N.,Penalva-Lopez, S.,Sharma, V.,Dolgov, E.,Cangialosi, J.,Sharma, P.,Nitsche, J.,Ganichkin, O.,Steinbacher, S.,Glickman, J.F.,Rice, C.M.,Perlin, D.S.,Tuschl, T.; A new class of small-molecule inhibitors targeting the SARS-CoV-2 mRNA cap methyltransferase NSP14; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.77 Å)