30PO

Apo Structure of a TrkB Agonist

Summary for 30PO

• Entry DOI: 10.2210/pdb30po/pdb
• Descriptor: ZEB85, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: agonist, biologic, antibody, protein binding
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 54300.95

Authors

Briggs, D.C.,McDonald, N.Q. (deposition date: 2026-05-07, release date: 2026-11-04)

• Primary citation: Briggs, D.C.,Duffy, R.,Ateaque, S.,Maslen, S.,Nagaraj, H.,Barde, Y.A.,DiStefano, P.S.,Lindsay, R.M.,Armstrong, P.C.,Peach, C.J.,McDonald, N.Q.; A sulfotyrosine-motif in the human TrkB extracellular domain is required for activation by the agonist antibody ZEB85; PNAS, 2026

Experimental method

X-RAY DIFFRACTION (1.88 Å)