30GR

DOTAM-TCB: Universal Small Molecule-Guided Hapten- and T Cell Bispecfic Antibodies for Cancer Immunotherapy

This is a non-PDB format compatible entry.

Summary for 30GR

• Entry DOI: 10.2210/pdb30gr/pdb
• Descriptor: FAB Fragment Heavy Chain, FAB Fragment Light chain, ~{N}-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-8-[[4-[[(2~{S})-1,4,7,10-tetrakis(2-azanyl-2-oxidanylidene-ethyl)-1,4,7,10-tetrazacyclododec-2-yl]methyl]phenyl]carbamothioylamino]octanamide, ... (5 entities in total)
• Functional Keywords: antibody, fab fragment, dotam, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 48329.12

Authors

Ehler, A.,Klein, C.,Surowka, M.,Venetz, D.,Benz, J. (deposition date: 2026-04-24, release date: 2026-10-14)

Primary citation

Surowka, M.,Kober, T.,Matscheko, D.,Ehler, A.,Macedo, W.,Assisi, D.,Challier, J.,Sobieniecki, A.,Gianotti, R.,Bransi, A.,Sam, J.,Bonfiglio, J.J.,Wichert, M.,Ricci, A.,Benz, J.,Umana, P.,Venetz, D.,Klein, C.
DOTAM-TCB: Universal Small Molecule-guided Hapten- and T Cell-bispecific Antibodies for Cancer Immunotherapy.
Antib Ther, 9:535-549, 2026

PubMed Abstract: Tumor heterogeneity has been identified as a major roadblock for cancer immunotherapy. To overcome this, universal effector cell engagers with interchangeable tumor-targeting adaptors have been developed. Current concepts in this field consist of antibody-based adaptors. Small-molecule (SM) ligands, on the other hand, infiltrate tissues rapidly, have short half-lives, and are potentially orally available. Therefore, we hypothesized that utilizing SM adaptors, combined with effector antibodies, could represent an attractive off-the-shelf therapy.

PubMed: 42824820
DOI: 10.1093/abt/tbag038

Experimental method

X-RAY DIFFRACTION (1.45 Å)