30AR

Cryo-EM structure of human PRIMPOL bound to the CMG helicase

This is a non-PDB format compatible entry.

Summary for 30AR

• Entry DOI: 10.2210/pdb30ar/pdb
• EMDB information: 57512
• Descriptor: DNA replication licensing factor MCM2, DNA replication complex GINS protein PSF2, DNA-directed primase/polymerase protein, ... (16 entities in total)
• Functional Keywords: primpol, primase, polymerase, cmg helicase, cmg, cdc45, gins, mcm, dna replication, restart, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 775076.61

Authors

Roske, J.J.,Polo Rivera, C.,Yeeles, J.T.P. (deposition date: 2026-04-17, release date: 2026-11-11)

• Primary citation: Polo Rivera, C.,Roske, J.J.,Hands, E.L.,Fassetta, F.,Sale, J.E.,Yeeles, J.T.P.; Human replisomes direct a dedicated leading-strand primase for fork restart; Nature, 2026; DOI: 10.1038/s41586-026-11204-0

Experimental method

ELECTRON MICROSCOPY (3.3 Å)