2ZZU

Human Factor VIIA-Tissue Factor Complexed with ethylsulfonamide-D-5-(3-carboxybenzyloxy)-Trp-Gln-p-aminobenzamidine

Summary for 2ZZU

• Entry DOI: 10.2210/pdb2zzu/pdb
• Related: 1WQV 1WSS 1WTG 1WUN 1WV7 2ZWL
• Descriptor: Factor VII light chain, Factor VII heavy chain, Tissue factor, ... (8 entities in total)
• Functional Keywords: serine protease, blood coagulation, cleavage on pair of basic residues, disease mutation, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydrolase, hydroxylation, protease, zymogen, lipoprotein, membrane, palmitate, transmembrane, hydrolase-blood clotting complex, secreted, hydrolase/blood clotting
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P08709 P08709; Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P13726
• Total number of polymer chains: 3
• Total formula weight: 71698.53

Authors

Kadono, S.,Sakamoto, A.,Kikuchi, Y.,Oh-Eda, M.,Yabuta, N.,Koga, T.,Hattori, K.,Shiraishi, T.,Haramura, M.,Sato, H.,Ohta, M.,Kozono, T. (deposition date: 2009-02-25, release date: 2009-03-24, Last modification date: 2023-11-15)

• Primary citation: Shiraishi, T.,Kadono, S.,Haramura, M.,Kodama, H.,Ono, Y.,Iikura, H.,Esaki, T.,Koga, T.,Hattori, K.,Watanabe, Y.,Sakamoto, A.,Yoshihashi, K.,Kitazawa, T.,Esaki, K.,Ohta, M.,Sato, H.,Kozono, T.; Design and synthesis of peptidomimetic factor VIIa inhibitors; Chem.Pharm.Bull., 58:38-44, 2010; PubMed: 20045964; DOI: 10.1248/cpb.58.38

Experimental method

X-RAY DIFFRACTION (2.5 Å)