2ZY0
Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide
Summary for 2ZY0
Entry DOI | 10.2210/pdb2zy0/pdb |
Related | 1FBY 1MV9 1MVC 2ZXZ |
Descriptor | Retinoic acid receptor RXR-alpha, GRIP1 from Nuclear receptor coactivator 2, 4-[2-(1,1,3,3-tetramethyl-2,3-dihydro-1H-1,3-benzodisilol-5-yl)-1,3-dioxolan-2-yl]benzoic acid, ... (4 entities in total) |
Functional Keywords | transcription regulation, nuclear receptor, structural genomics, structural genomics consortium for research on gene expression, sgcges, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P19793 Q15596 |
Total number of polymer chains | 4 |
Total formula weight | 57669.01 |
Authors | Sato, Y.,Antony, P.,Rochel, N.,Moras, D.,Structural Genomics Consortium for Research on Gene Expression (SGCGES) (deposition date: 2009-01-09, release date: 2009-08-11, Last modification date: 2023-11-01) |
Primary citation | Lippert, W.P.,Burschka, C.,Gotz, K.,Kaupp, M.,Ivanova, D.,Gaudon, C.,Sato, Y.,Antony, P.,Rochel, N.,Moras, D.,Gronemeyer, H.,Tacke, R. Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology Chemmedchem, 4:1143-1152, 2009 Cited by PubMed: 19496083DOI: 10.1002/cmdc.200900090 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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