2ZVJ

Crystal structures of rat Catechol-O-Methyltransferase complexed with coumarine-based inhibitor

2ZVJ の概要

• エントリーDOI: 10.2210/pdb2zvj/pdb
• 関連するPDBエントリー: 1H1D 1JR4 1VID 2CL5
• 分子名称: Catechol O-methyltransferase, MAGNESIUM ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
• 機能のキーワード: transferase, methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, cell membrane, cytoplasm, magnesium, membrane, metal-binding, phosphoprotein, s-adenosyl-l-methionine, signal-anchor, transmembrane
• 由来する生物種: Rattus norvegicus (Rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25593.51

構造登録者

Tsuji, E. (登録日: 2008-11-07, 公開日: 2009-01-06, 最終更新日: 2023-11-01)

• 主引用文献: Tsuji, E.,Okazaki, K.,Takeda, K.; Crystal structures of rat catechol-O-methyltransferase complexed with coumarine-based inhibitor; Biochem.Biophys.Res.Commun., 378:494-497, 2009; PubMed: 19056347; DOI: 10.1016/j.bbrc.2008.11.085

実験手法

X-RAY DIFFRACTION (2.3 Å)