2ZU5
complex structure of SARS-CoV 3CL protease with TG-0205486
Summary for 2ZU5
Entry DOI | 10.2210/pdb2zu5/pdb |
Related | 2ZTX 2ZTY 2ZTZ 2ZU1 2ZU2 2ZU3 2ZU4 |
Related PRD ID | PRD_000569 |
Descriptor | 3C-like proteinase, N-[(benzyloxy)carbonyl]-O-tert-butyl-L-threonyl-N-[(1R)-4-cyclopropyl-4-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}butyl]-L-leucinamide (3 entities in total) |
Functional Keywords | protease-inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | SARS coronavirus (SARS-CoV) |
Total number of polymer chains | 1 |
Total formula weight | 34505.44 |
Authors | Hsu, M.F.,Lee, C.C.,Wang, A.H.-J. (deposition date: 2008-10-12, release date: 2009-01-13, Last modification date: 2023-11-01) |
Primary citation | Lee, C.C.,Kuo, C.J.,Ko, T.P.,Hsu, M.F.,Tsui, Y.C.,Chang, S.C.,Yang, S.,Chen, S.J.,Chen, H.C.,Hsu, M.C.,Shih, S.R.,Liang, P.H.,Wang, A.H.-J. Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds J.Biol.Chem., 284:7646-7655, 2009 Cited by PubMed: 19144641DOI: 10.1074/jbc.M807947200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report