2ZTW

Structure of 3-isopropylmalate dehydrogenase in complex with the inhibitor and NAD+

2ZTW の概要

• エントリーDOI: 10.2210/pdb2ztw/pdb
• 分子名称: 3-isopropylmalate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (2Z)-2-hydroxy-3-(methylsulfanyl)prop-2-enoic acid, ... (5 entities in total)
• 機能のキーワード: 3-isopropylmalate dehydrogenase, ipmdh, decarboxylating dehydrogenase, leucine biosynthesis, amino-acid biosynthesis, branched-chain amino acid biosynthesis, cytoplasm, magnesium, manganese, metal-binding, nad, oxidoreductase
• 由来する生物種: Thermus thermophilus
• 細胞内の位置: Cytoplasm: Q5SIY4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37647.04

構造登録者

Nango, E.,Kumasaka, T.,Eguchi, T. (登録日: 2008-10-10, 公開日: 2009-10-13, 最終更新日: 2023-11-01)

• 主引用文献: Nango, E.,Yamamoto, T.,Kumasaka, T.,Eguchi, T.; Crystal structure of 3-isopropylmalate dehydrogenase in complex with NAD(+) and a designed inhibitor; Bioorg.Med.Chem., 17:7789-7794, 2009; PubMed: 19833522; DOI: 10.1016/j.bmc.2009.09.025

実験手法

X-RAY DIFFRACTION (2.79 Å)