2ZTJ

Crystal structure of homocitrate synthase from Thermus thermophilus complexed with alpha-ketoglutarate

Summary for 2ZTJ

• Entry DOI: 10.2210/pdb2ztj/pdb
• Related: 2ZJK
• Descriptor: Homocitrate synthase, 2-OXOGLUTARIC ACID, COPPER (II) ION, ... (4 entities in total)
• Functional Keywords: (beta/alpha)8 tim barrel, substrate complex, amino-acid biosynthesis, lysine biosynthesis, transferase
• Biological source: Thermus thermophilus
• Cellular location: Cytoplasm (Potential): O87198
• Total number of polymer chains: 1
• Total formula weight: 43283.70

Authors

Okada, T.,Tomita, T.,Kuzuyama, T.,Nishiyama, M. (deposition date: 2008-10-06, release date: 2009-10-13, Last modification date: 2024-03-13)

• Primary citation: Okada, T.,Tomita, T.,Wulandari, A.P.,Kuzuyama, T.,Nishiyama, M.; Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from Thermus thermophilus; J.Biol.Chem., 285:4195-4205, 2010; PubMed: 19996101; DOI: 10.1074/jbc.M109.086330

Experimental method

X-RAY DIFFRACTION (1.8 Å)