2ZTH

Crystal structure of holo form of rat catechol-o-methyltransferase

Summary for 2ZTH

Entry DOI	10.2210/pdb2zth/pdb
Related	1vid
Descriptor	Catechol O-methyltransferase, MAGNESIUM ION, S-ADENOSYLMETHIONINE, ... (4 entities in total)
Functional Keywords	s-adenosylmethionine dependent methyltransferase, alternative initiation, catecholamine metabolism, cell membrane, cytoplasm, magnesium, membrane, metal-binding, methyltransferase, neurotransmitter degradation, phosphoprotein, s-adenosyl-l-methionine, signal-anchor, transferase, transmembrane
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
Total number of polymer chains	1
Total formula weight	25339.27
Authors	Tsuji, E. (deposition date: 2008-10-01, release date: 2009-01-13, Last modification date: 2023-11-01)
Primary citation	Tsuji, E.,Okazaki, K.,Isaji, M.,Takeda, K. Crystal structures of the Apo and Holo form of rat catechol-O-methyltransferase J.Struct.Biol., 165:133-139, 2009 Cited by PubMed: 19111934 DOI: 10.1016/j.jsb.2008.11.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation