2ZPX
TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity; R1antTNF-T8
Summary for 2ZPX
Entry DOI | 10.2210/pdb2zpx/pdb |
Related | 1TNF 1TNR 2EA7 2ZJC |
Descriptor | Tumor necrosis factor (2 entities in total) |
Functional Keywords | tumor necrosis factor, trimer, antagonistic activity, tnfr1 specific, phage display system, cytokine, cell membrane, lipoprotein, membrane, myristate, phosphoprotein, polymorphism, secreted, signal-anchor, transmembrane |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted: P01375 |
Total number of polymer chains | 3 |
Total formula weight | 51850.31 |
Authors | Mukai, Y.,Nakamura, T.,Yamagata, Y.,Tsutsumi, Y. (deposition date: 2008-07-29, release date: 2009-03-24, Last modification date: 2023-11-01) |
Primary citation | Mukai, Y.,Nakamura, T.,Yoshioka, Y.,Shibata, H.,Abe, Y.,Nomura, T.,Taniai, M.,Ohta, T.,Nakagawa, S.,Tsunoda, S.,Kamada, H.,Yamagata, Y.,Tsutsumi, Y. Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists J.Biochem., 146:167-172, 2009 Cited by PubMed: 19386778DOI: 10.1093/jb/mvp065 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.83 Å) |
Structure validation
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