2ZPX

TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity; R1antTNF-T8

2ZPX の概要

• エントリーDOI: 10.2210/pdb2zpx/pdb
• 関連するPDBエントリー: 1TNF 1TNR 2EA7 2ZJC
• 分子名称: Tumor necrosis factor (2 entities in total)
• 機能のキーワード: tumor necrosis factor, trimer, antagonistic activity, tnfr1 specific, phage display system, cytokine, cell membrane, lipoprotein, membrane, myristate, phosphoprotein, polymorphism, secreted, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted: P01375
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 51850.31

構造登録者

Mukai, Y.,Nakamura, T.,Yamagata, Y.,Tsutsumi, Y. (登録日: 2008-07-29, 公開日: 2009-03-24, 最終更新日: 2023-11-01)

• 主引用文献: Mukai, Y.,Nakamura, T.,Yoshioka, Y.,Shibata, H.,Abe, Y.,Nomura, T.,Taniai, M.,Ohta, T.,Nakagawa, S.,Tsunoda, S.,Kamada, H.,Yamagata, Y.,Tsutsumi, Y.; Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists; J.Biochem., 146:167-172, 2009; PubMed: 19386778; DOI: 10.1093/jb/mvp065

実験手法

X-RAY DIFFRACTION (2.83 Å)