2ZP0

Human factor viia-tissue factor complexed with benzylsulfonamide-D-ile-gln-P-aminobenzamidine

Summary for 2ZP0

• Entry DOI: 10.2210/pdb2zp0/pdb
• Descriptor: Factor VII light chain, Factor VII heavy chain, Tissue factor, ... (8 entities in total)
• Functional Keywords: serine protease, blood coagulation, cleavage on pair of basic residues, disease mutation, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydrolase, hydroxylation, protease, zymogen, lipoprotein, membrane, palmitate, transmembrane, hydrolase-blood clotting complex, hydrolase/blood clotting
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P08709 P08709; Membrane; Single-pass type I membrane protein: P13726
• Total number of polymer chains: 3
• Total formula weight: 71537.41

Authors

Kadono, S.,Sakamoto, A.,Kikuchi, Y.,Oh-eda, M.,Yabuta, N.,Koga, T.,Hattori, K.,Shiraishi, T.,Haramura, M.,Kodama, H. (deposition date: 2008-06-20, release date: 2008-07-15, Last modification date: 2023-11-15)

• Primary citation: Kadono, S.,Sakamoto, A.,Kikuchi, Y.,Oh-eda, M.,Yabuta, N.,Koga, T.,Hattori, K.,Shiraishi, T.,Haramura, M.,Kodama, H.,Esaki, T.,Sato, H.,Watanabe, S.,Itoh, S.,Ohta, M.,Kozono, T.; Peptide Mimetic Factor VIIa Inhibitor: Importance of Hydrophilic Pocket in S2 Site to Improve Selectivity aganist Thrombin; LETT.DRUG DES.DISCOVERY, 2:177-181, 2005

Experimental method

X-RAY DIFFRACTION (2.7 Å)