2ZNU

Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, neodysiherbaine A

2ZNU の概要

• エントリーDOI: 10.2210/pdb2znu/pdb
• 関連するPDBエントリー: 2ZNS 2ZNT
• 分子名称: Glutamate receptor, ionotropic kainate 1, (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, BETA-MERCAPTOETHANOL, ... (4 entities in total)
• 機能のキーワード: glur5, ligand-binding core, neodysiherbaine a, agonist, alternative splicing, cell junction, glycoprotein, ion transport, ionic channel, membrane, phosphoprotein, polymorphism, postsynaptic cell membrane, rna editing, synapse, transmembrane, transport, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P39086
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29697.23

構造登録者

Unno, M.,Sasaki, M.,Ikeda-Saito, M. (登録日: 2008-05-01, 公開日: 2009-05-05, 最終更新日: 2023-11-01)

• 主引用文献: Unno, M.,Shinohara, M.,Takayama, K.,Tanaka, H.,Teruya, K.,Doh-Ura, K.,Sakai, R.,Sasaki, M.,Ikeda-Saito, M.; Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.; J.Mol.Biol., 413:667-683, 2011; PubMed: 21893069; DOI: 10.1016/j.jmb.2011.08.043

実験手法

X-RAY DIFFRACTION (1.8 Å)