2ZMH

Crystal Structure of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and/or Partial Agonism

Summary for 2ZMH

• Entry DOI: 10.2210/pdb2zmh/pdb
• Related: 2ZMI 2ZMJ
• Descriptor: Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3R,7E,17beta)-17-{(1R,2E,4R)-4-hydroxy-1-methyl-4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]but-2-en-1-yl}-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
• Functional Keywords: nuclear receptor-antagonist complex, dna-binding, metal-binding, nucleus, phosphoprotein, transcription, transcription regulation, zinc, zinc-finger, activator
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Nucleus: P13053; Nucleus (By similarity): A1L0Z0
• Total number of polymer chains: 2
• Total formula weight: 32672.69

Authors

Nakabayashi, M.,Yamada, S.,Tanaka, T.,Igarashi, M.,Yoshimoto, N.,Ikura, T.,Ito, N.,Makishima, M.,Tokiwa, H.,DeLuca, H.F.,Shimizu, M. (deposition date: 2008-04-18, release date: 2008-09-02, Last modification date: 2024-03-13)

• Primary citation: Nakabayashi, M.,Yamada, S.,Yoshimoto, N.,Tanaka, T.,Igarashi, M.,Ikura, T.,Ito, N.,Makishima, M.,Tokiwa, H.,DeLuca, H.F.,Shimizu, M.; Crystal structures of rat vitamin d receptor bound to adamantyl vitamin d analogs: structural basis for vitamin d receptor antagonism and partial agonism; J.Med.Chem., 51:5320-5329, 2008; PubMed: 18710208; DOI: 10.1021/jm8004477

Experimental method

X-RAY DIFFRACTION (2.1 Å)