2ZK4

Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 15-oxo-eicosatetraenoic acid

Summary for 2ZK4

Entry DOI	10.2210/pdb2zk4/pdb
Related	2ZK0 2ZK1 2ZK2 2ZK3 2ZK5 2ZK6
Descriptor	Peroxisome proliferator-activated receptor gamma, (5E,8E,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoic acid (3 entities in total)
Functional Keywords	anti parallel helix sandwich, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	65698.20
Authors	Waku, T.,Shiraki, T.,Oyama, T.,Fujimoto, Y.,Morikawa, K. (deposition date: 2008-03-12, release date: 2009-02-24, Last modification date: 2023-11-01)
Primary citation	Waku, T.,Shiraki, T.,Oyama, T.,Fujimoto, Y.,Maebara, K.,Kamiya, N.,Jingami, H.,Morikawa, K. Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids J.Mol.Biol., 385:188-199, 2009 Cited by PubMed: 18977231 DOI: 10.1016/j.jmb.2008.10.039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.57 Å)

Structure validation