Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2ZJJ

Crystal structure of the human BACE1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid (2-mercapto-ethyl)-amide

Summary for 2ZJJ
Entry DOI10.2210/pdb2zjj/pdb
Related2ZJH 2ZJI 2ZJK 2ZJL 2ZJM 2ZJN
DescriptorBeta-secretase 1, (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide (3 entities in total)
Functional Keywordsbace1, small-molecule inhibitor, tethering, aspartyl protease, glycoprotein, hydrolase, membrane, protease, transmembrane, zymogen
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein: P56817
Total number of polymer chains1
Total formula weight45422.18
Authors
Randal, M.,Lam, M.B.,Romanowski, M.J. (deposition date: 2008-03-07, release date: 2009-01-20, Last modification date: 2023-11-01)
Primary citationYang, W.,Fucini, R.V.,Fahr, B.T.,Randal, M.,Lind, K.E.,Lam, M.B.,Lu, W.,Lu, Y.,Cary, D.R.,Romanowski, M.J.
Fragment-based discovery of novel BACE1 inhibitors using Tethering technology
To be Published,
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

數據於2024-03-27公開中

PDB statisticsPDBj update infoContact PDBjnumon