Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2ZJJ

Crystal structure of the human BACE1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid (2-mercapto-ethyl)-amide

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
A0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE F1J A 449
ChainResidue
AGLY11
ACYS231
ATHR232
AHOH450
AGLN12
AGLY13
ALEU30
ATYR71
ATHR72
AGLN73
APHE108
AGLY230

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV
ChainResidueDetails
AILE29-VAL40

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094
ChainResidueDetails
AASP32
AASP228

site_idSWS_FT_FI2
Number of Residues7
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17425515, ECO:0000269|PubMed:19011241
ChainResidueDetails
ALYS65
ALYS214
ALYS218
ALYS224
ALYS238
ALYS239
ALYS246

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN92
AASN111
AASN162
AASN293

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1avf
ChainResidueDetails
AASP228
ASER229
AASP32
ATHR33

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1avf
ChainResidueDetails
AASP228
ASER35
AASP32

site_idCSA3
Number of Residues4
DetailsAnnotated By Reference To The Literature 1avf
ChainResidueDetails
AASP228
ASER35
ATYR71
AASP32

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1avf
ChainResidueDetails
AASP32

site_idCSA5
Number of Residues1
DetailsAnnotated By Reference To The Literature 1avf
ChainResidueDetails
AASP228

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon