2ZJC

TNFR1 selectve TNF mutant; R1-6

Summary for 2ZJC

• Entry DOI: 10.2210/pdb2zjc/pdb
• Related: 2E7A
• Descriptor: Tumor necrosis factor, GLYCEROL (3 entities in total)
• Functional Keywords: phage display system, tnfr1 selectivity, tnf, agonist, mutant, cytokine, lipoprotein, membrane, myristate, phosphoprotein, secreted, signal-anchor, transmembrane
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted: P01375
• Total number of polymer chains: 3
• Total formula weight: 51335.49

Authors

Mukai, Y.,Yamagata, Y.,Tsutsumi, Y. (deposition date: 2008-03-05, release date: 2009-01-20, Last modification date: 2023-11-01)

• Primary citation: Mukai, Y.,Shibata, H.,Nakamura, T.,Yoshioka, Y.,Abe, Y.,Nomura, T.,Taniai, M.,Ohta, T.,Ikemizu, S.,Nakagawa, S.,Tsunoda, S.,Kamada, H.,Yamagata, Y.,Tsutsumi, Y.; Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant; J.Mol.Biol., 385:1221-1229, 2009; PubMed: 19084540; DOI: 10.1016/j.jmb.2008.11.053

Experimental method

X-RAY DIFFRACTION (2.5 Å)