2ZIA

C4S dCK variant of dCK in complex with cladribine+UDP

2ZIA の概要

• エントリーDOI: 10.2210/pdb2zia/pdb
• 関連するPDBエントリー: 1P60 2NO1 2NO7 2ZI3 2ZI4 2ZI5 2ZI6 2ZI7 2ZI9
• 分子名称: Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE, 2-chloro-2'-deoxyadenosine, ... (4 entities in total)
• 機能のキーワード: dck, purine, deoxycytidine kinase, nucleoside, cladribine, 2-chloro-2'-deoxyadenosine, deoxyadenosine analog, udp, atp-binding, nucleotide-binding, nucleus, phosphoprotein, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P27707
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66524.72

構造登録者

Sabini, E.,Lavie, A. (登録日: 2008-02-13, 公開日: 2008-07-08, 最終更新日: 2023-11-01)

• 主引用文献: Sabini, E.,Hazra, S.,Konrad, M.,Lavie, A.; Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase; J.Med.Chem., 51:4219-4225, 2008; PubMed: 18570408; DOI: 10.1021/jm800134t

実験手法

X-RAY DIFFRACTION (1.8 Å)