2ZI8

Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)

Summary for 2ZI8

• Entry DOI: 10.2210/pdb2zi8/pdb
• Related: 2ZF1
• Descriptor: PROBABLE BIPHENYL-2,3-DIOL 1,2-DIOXYGENASE BPHC, FE (II) ION, 3,4-dihydroxy-9,10-secoandrosta-1(10),2,4-triene-9,17-dione, ... (4 entities in total)
• Functional Keywords: dhsa, hsac, extradiol dioxygenase, mycobacterium tuberculosis, aromatic hydrocarbons catabolism, iron, oxidoreductase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 68001.10

Authors

D'Angelo, I.,Yam, K.C.,Eltis, L.D.,Strynadka, N. (deposition date: 2008-02-13, release date: 2009-02-24, Last modification date: 2023-11-01)

• Primary citation: Yam, K.C.,D'Angelo, I.,Kalscheuer, R.,Zhu, H.,Wang, J.X.,Snieckus, V.,Ly, L.H.,Converse, P.J.,Jacobs, W.R.,Strynadka, N.,Eltis, L.D.; Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.; Plos Pathog., 5:e1000344-e1000344, 2009; PubMed: 19300498; DOI: 10.1371/journal.ppat.1000344

Experimental method

X-RAY DIFFRACTION (2.2 Å)