2ZI2

Thrombin Inhibition

2ZI2 の概要

• エントリーDOI: 10.2210/pdb2zi2/pdb
• 関連するPDBエントリー: 2ZC9 2ZDA 2ZFP 2ZGB 2ZGX 2ZHQ
• 関連するBIRD辞書のPRD_ID: PRD_000595
• 分子名称: Thrombin light chain, Thrombin heavy chain, Hirudin variant-1, ... (7 entities in total)
• 機能のキーワード: blood clotting, hydrolase inhibitors, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, kringle, protease, secreted, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P01050
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35779.73

構造登録者

Baum, B.,Heine, A.,Klebe, G. (登録日: 2008-02-13, 公開日: 2009-01-13, 最終更新日: 2023-11-15)

• 主引用文献: Baum, B.,Muley, L.,Smolinski, M.,Heine, A.,Hangauer, D.,Klebe, G.; Non-additivity of functional group contributions in protein-ligand binding: a comprehensive study by crystallography and isothermal titration calorimetry.; J.Mol.Biol., 397:1042-1054, 2010; PubMed: 20156458; DOI: 10.1016/j.jmb.2010.02.007

実験手法

X-RAY DIFFRACTION (1.65 Å)