2ZHP

Crystal structure of bleomycin-binding protein from Streptoalloteichus hindustanus complexed with bleomycin derivative

Summary for 2ZHP

• Entry DOI: 10.2210/pdb2zhp/pdb
• Related: 1BYL 1XRK
• Descriptor: Bleomycin resistance protein, [(2S,3R,4R,5S,6S)-2-[(3R,4R,5R,6R)-2-[(1R,2S)-2-[[6-amino-2-[(1S)-3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2S,3R,4R)-5-[[(2R,3S)-1-[2-[4-[4-[3-[4-(3-aminopropylamino)butylamino]propylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-4-methyl-5-oxopentan-2-yl]amino]-1-(3H-imidazol-4-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate, COPPER (II) ION, ... (5 entities in total)
• Functional Keywords: antibiotic resistance, bleomycin, ligand binding protein, antibiotic inhibitor
• Biological source: Streptoalloteichus hindustanus
• Total number of polymer chains: 2
• Total formula weight: 30841.19

Authors

Okumura, H.,Miyazaki, I.,Simizu, S.,Osada, H. (deposition date: 2008-02-06, release date: 2009-02-17, Last modification date: 2024-03-13)

• Primary citation: Miyazaki, I.,Okumura, H.,Simizu, S.,Takahashi, Y.,Kanoh, N.,Nonomura, Y.,Osada, H.; Structure-Affinity Relationship Study of Bleomycins and Shble protein Using a Chemical Array; To be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)