2ZEV

S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium, IPP and BPH-715

2ZEV の概要

• エントリーDOI: 10.2210/pdb2zev/pdb
• 関連するPDBエントリー: 2DH4 2E8T 2E8U 2E8V 2E8W 2E8X 2E90 2E91 2E92 2E93 2E94 2E95 2ZEU
• 分子名称: Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, ... (5 entities in total)
• 機能のキーワード: prenyltransferase, farnesyl pyrophosphate, bisphosphonate, carotenoid biosynthesis, isoprene biosynthesis, multifunctional enzyme, protein transport, transport, transferase
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast)
• 細胞内の位置: Cytoplasm (By similarity): Q12051
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79790.20

構造登録者

Guo, R.T.,Chen, C.K.-M.,Cao, R.,Oldfield, E.,Wang, A.H.-J. (登録日: 2007-12-17, 公開日: 2008-12-23, 最終更新日: 2023-11-01)

• 主引用文献: Zhang, Y.,Cao, R.,Yin, F.,Hudock, M.P.,Guo, R.T.,Krysiak, K.,Mukherjee, S.,Gao, Y.-G.,Robinson, H.,Song, Y.,No, J.H.,Bergan, K.,Leon, A.,Cass, L.,Goddard, A.,Chang, T.-K.,Lin, F.-Y.,Van Beek, E.,Papapoulos, S.,Wang, A.H.-J.,Kubo, T.,Ochi, M.,Mukkamala, D.,Oldfield, E.; Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation; J.Am.Chem.Soc., 131:5153-5162, 2009; PubMed: 19309137; DOI: 10.1021/ja808285e

実験手法

X-RAY DIFFRACTION (2.23 Å)