2ZEG

Crystal structure of the human glutaminyl cyclase mutant E201L at 2.08 angstrom resolution

Summary for 2ZEG

Entry DOI	10.2210/pdb2zeg/pdb
Related	2AFM 2ZED 2ZEE 2ZEF 2ZEH 2ZEL 2ZEM 2ZEN 2ZEO 2ZEP
Descriptor	Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	hydrogen bond network, glutaminyl cyclase, pyroglutamate, site-directed mutagenesis, proton transfer, acyltransferase, glycoprotein, metal-binding, transferase
Biological source	Homo sapiens (human)
Cellular location	Secreted: Q16769
Total number of polymer chains	2
Total formula weight	75544.00
Authors	Huang, K.F.,Wang, Y.R.,Chang, E.C.,Chou, T.L.,Wang, A.H. (deposition date: 2007-12-12, release date: 2008-04-22, Last modification date: 2023-11-01)
Primary citation	Huang, K.F.,Wang, Y.R.,Chang, E.C.,Chou, T.L.,Wang, A.H. A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis. Biochem.J., 411:181-190, 2008 Cited by PubMed: 18072935 DOI: 10.1042/BJ20071073 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation