2ZA5

Crystal Structure of human tryptase with potent non-peptide inhibitor

2ZA5 の概要

• エントリーDOI: 10.2210/pdb2za5/pdb
• 分子名称: Tryptase beta 2, (5-(aminomethyl)-2H-spiro[benzofuran-3,4'-piperidine]-1'-yl)(5-(phenylethynyl)furan-2-yl)methanone (3 entities in total)
• 機能のキーワード: tryptase, serine protease, tetramer, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 111615.62

構造登録者

Spurlino, J.C.,Barnakov, S.A.,Lewandowski, F.,Milligan, C. (登録日: 2007-10-02, 公開日: 2008-02-26, 最終更新日: 2023-11-01)

• 主引用文献: Costanzo, M.J.,Yabut, S.C.,Zhang, H.-C.,White, K.B.,de Garavilla, L.,Wang, Y.,Minor, L.K.,Tounge, B.A.,Barnakov, A.N.,Lewandowski, F.,Milligan, C.,Spurlino, J.C.,Abraham, W.M.,Boswell-Smith, V.,Page, C.P.,Maryanoff, B.E.; Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives; Bioorg.Med.Chem.Lett., 18:2114-2121, 2008; PubMed: 18272363; DOI: 10.1016/j.bmcl.2008.01.093

実験手法

X-RAY DIFFRACTION (2.3 Å)