2Z7S

Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A

Summary for 2Z7S

• Entry DOI: 10.2210/pdb2z7s/pdb
• Related: 2Z7Q 2Z7R
• Descriptor: Ribosomal protein S6 kinase alpha-1, 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL (3 entities in total)
• Functional Keywords: protein kinase, cancer, kinase inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 37166.29

Authors

Ikuta, M.,Munshi, S.K. (deposition date: 2007-08-28, release date: 2008-05-13, Last modification date: 2023-11-01)

• Primary citation: Ikuta, M.,Kornienko, M.,Byrne, N.,Reid, J.C.,Mizuarai, S.,Kotani, H.,Munshi, S.K.; Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors.; Protein Sci., 16:2626-2635, 2007; PubMed: 17965187; DOI: 10.1110/ps.073123707

Experimental method

X-RAY DIFFRACTION (2.1 Å)