2Z7I
S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with inhibitor BPH-742
Summary for 2Z7I
Entry DOI | 10.2210/pdb2z7i/pdb |
Related | 2Z7H |
Descriptor | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM, ... (4 entities in total) |
Functional Keywords | prenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, carotenoid biosynthesis, isoprene biosynthesis, multifunctional enzyme, protein transport, transport, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) |
Cellular location | Cytoplasm (By similarity): Q12051 |
Total number of polymer chains | 2 |
Total formula weight | 79485.51 |
Authors | Guo, R.T.,Chen, C.K.-M.,Ko, T.-P.,Cao, R.,Hudock, M.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-08-23, release date: 2008-07-08, Last modification date: 2023-11-01) |
Primary citation | Chen, C.K.-M.,Hudock, M.P.,Zhang, Y.,Guo, R.-T.,Cao, R.,No, J.H.,Liang, P.-H.,Ko, T.-P.,Chang, T.-H.,Chang, S.-C.,Song, Y.,Axelson, J.,Kumar, A.,Wang, A.H.-J.,Oldfield, E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51:5594-5607, 2008 Cited by PubMed: 18800762DOI: 10.1021/jm800325y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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