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2Z4W

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-749

Summary for 2Z4W
Entry DOI10.2210/pdb2z4w/pdb
Related2Z4V 2Z4X 2Z4Y 2Z4Z 2Z50 2Z52
DescriptorGeranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, [(6E,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyl]bis(phosphonic acid), ... (4 entities in total)
Functional Keywordsprenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm (By similarity): Q12051
Total number of polymer chains2
Total formula weight79592.28
Authors
Chen, C.K.-M.,Guo, R.T.,Hudock, M.,Cao, R.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-06-26, release date: 2008-07-01, Last modification date: 2023-11-01)
Primary citationChen, C.K.-M.,Hudock, M.P.,Zhang, Y.,Guo, R.-T.,Cao, R.,No, J.H.,Liang, P.-H.,Ko, T.-P.,Chang, T.-H.,Chang, S.-C.,Song, Y.,Axelson, J.,Kumar, A.,Wang, A.H.-J.,Oldfield, E.
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51:5594-5607, 2008
Cited by
PubMed: 18800762
DOI: 10.1021/jm800325y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.45 Å)
Structure validation

217705

数据于2024-03-27公开中

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