2Z4V
S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site)
Summary for 2Z4V
Entry DOI | 10.2210/pdb2z4v/pdb |
Related | 2Z4W 2Z4X 2Z4Y 2Z4Z 2Z50 2Z52 |
Descriptor | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, GERANYLGERANYL DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | prenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, transferase |
Biological source | Saccharomyces cerevisiae (Baker's yeast) |
Cellular location | Cytoplasm (By similarity): Q12051 |
Total number of polymer chains | 2 |
Total formula weight | 79596.22 |
Authors | Chen, C.K.-M.,Guo, R.T.,Hudock, M.,Cao, R.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-06-26, release date: 2008-07-01, Last modification date: 2023-11-01) |
Primary citation | Chen, C.K.-M.,Hudock, M.P.,Zhang, Y.,Guo, R.-T.,Cao, R.,No, J.H.,Liang, P.-H.,Ko, T.-P.,Chang, T.-H.,Chang, S.-C.,Song, Y.,Axelson, J.,Kumar, A.,Wang, A.H.-J.,Oldfield, E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51:5594-5607, 2008 Cited by PubMed: 18800762DOI: 10.1021/jm800325y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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