2Z2W
Human Wee1 kinase complexed with inhibitor PF0335770
Summary for 2Z2W
Entry DOI | 10.2210/pdb2z2w/pdb |
Related | 1X8B 2IN6 2IO6 |
Descriptor | Wee1-like protein kinase, CHLORIDE ION, N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE, ... (5 entities in total) |
Functional Keywords | wee1 kinase, inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P30291 |
Total number of polymer chains | 1 |
Total formula weight | 32701.98 |
Authors | Squire, C.J.,Baker, E.N. (deposition date: 2007-05-29, release date: 2008-05-06, Last modification date: 2023-11-15) |
Primary citation | Squire, C.J.,Baker, E.N. Synthesis and Structure-Activity Relationships of 9-Amino-4-(2-chlorophenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones and Related Formamides as Inhibitors of the Wee1 and Chk1 Checkpoint Kinases To be Published, |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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