Summary for 2YPT
| Descriptor | CAAX PRENYL PROTEASE 1 HOMOLOG, PRELAMIN-A/C, ZINC ION (3 entities in total) |
|---|---|
| Functional Keywords | hydrolase-peptide complex, m48 peptidase, integral membrane protein, prelamin a processing, ageing, progeria, hydrolase/peptide |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Endoplasmic reticulum membrane ; Multi-pass membrane protein O75844 Nucleus. Isoform C: Nucleus speckle P02545 |
| Total number of polymer chains | 8 |
| Total molecular weight | 224665.88 |
| Authors | Pike, A.C.W.,Dong, Y.Y.,Quigley, A.,Dong, L.,Savitsky, P.,Cooper, C.D.O.,Chaikuad, A.,Goubin, S.,Shrestha, L.,Li, Q.,Mukhopadhyay, S.,Yang, J.,Xia, X.,Shintre, C.A.,Barr, A.J.,Berridge, G.,Chalk, R.,Bray, J.E.,von Delft, F.,Bullock, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Burgess-Brown, N.,Carpenter, E.P. (deposition date: 2012-11-01, release date: 2012-12-05, Last modification date: 2018-01-24) |
| Primary citation | Quigley, A.,Dong, Y.Y.,Pike, A.C.W.,Dong, L.,Shrestha, L.,Berridge, G.,Stansfeld, P.J.,Sansom, M.S.P.,Edwards, A.M.,Bountra, C.,von Delft, F.,Bullock, A.N.,Burgess-Brown, N.A.,Carpenter, E.P. The Structural Basis of Zmpste24-Dependent Laminopathies. Science, 339:1604-, 2013 PubMed: 23539603 (PDB entries with the same primary citation) DOI: 10.1126/SCIENCE.1231513  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (3.8 Å) |
