2YDP

Structure of the E242A mutant of the alpha-l-arabinofuranosidase arb93a from fusarium graminearum in complex with an iminosugar inhibitor

2YDP の概要

• エントリーDOI: 10.2210/pdb2ydp/pdb
• 関連するPDBエントリー: 2YDT
• 分子名称: EXO-1,5-ALPHA-L-ARABINOFURANOBIOSIDASE, 1,4-DIDEOXY-1,4-IMINO-L-ARABINITOL, alpha-L-arabinofuranose, ... (5 entities in total)
• 機能のキーワード: hydrolase, glycosyl hydrolase
• 由来する生物種: GIBBERELLA ZEAE
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 124160.03

構造登録者

Goddard-Borger, E.D.,Carapito, R.,Jeltsch, J.M.,Phalip, V.,Stick, R.V.,Varrot, A. (登録日: 2011-03-24, 公開日: 2011-07-13, 最終更新日: 2023-12-20)

主引用文献

Goddard-Borger, E.D.,Carapito, R.,Jeltsch, J.,Phalip, V.,Stick, R.V.,Varrot, A.
Alpha-L-Arabinofuranosylated Pyrrolidines as Arabinanase Inhibitors.
Chem.Commun.(Camb.), 47:9684-, 2011

PubMed Abstract: As part of continued efforts to understand the mechanisms of 1,5-α-l-arabinanases better, some arabinan-like iminosugar oligosaccharides were synthesized. An iminosugar analogue of arabinobiose was found to be a good inhibitor of the arabinanase Arb93A from Fusarium graminearum. Structures were determined for complexes of this inhibitor with wild-type Arb93A and a catalytically inactive mutant.

PubMed: 21773614
DOI: 10.1039/C1CC13675E

実験手法

X-RAY DIFFRACTION (1.85 Å)