2YAD

BRICHOS domain of Surfactant protein C precursor protein

Summary for 2YAD

DescriptorSURFACTANT PROTEIN C BRICHOS DOMAIN (2 entities in total)
Functional Keywordspulmonary surfactant system, interstitial lung disease, amyloid, chaperone, surfactant protein
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains6
Total molecular weight112253.3
Authors
Primary citation
Willander, H.,Askarieh, G.,Landreh, M.,Westermark, P.,Nordling, K.,Keranen, H.,Hermansson, E.,Hamvas, A.,Nogee, L.M.,Bergman, T.,Saenz, A.,Casals, C.,Aqvist, J.,Jornvall, H.,Berglund, H.,Presto, J.,Knight, S.D.,Johansson, J.
High Resolution Structure of a Bricos Domain and its Implications for Anti-Amyloid Chaperone Activity on Lung Surgactant Protein C.
Proc.Natl.Acad.Sci.USA, 109:2325-, 2012
PubMed: 22308375 (PDB entries with the same primary citation)
DOI: 10.1073/PNAS.1114740109
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.225501.3%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2yad
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Molmil generated image of 2yad
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Molmil generated image of 2yad
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2yad
no rotation
Molmil generated image of 2yad
rotated about x axis by 90°
Molmil generated image of 2yad
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2yad.pdb2.gz [80.37 KB])
Coordinate files for Biological unit (2yad.pdb1.gz [77.04 KB])
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