2YAC

Crystal structure of Polo-like kinase 1 in complex with NMS-P937

Summary for 2YAC

Entry DOI	10.2210/pdb2yac/pdb
Related	1Q4K 1Q4O 1UMW 2V5Q
Descriptor	SERINE/THREONINE-PROTEIN KINASE PLK1, 1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE, ZINC ION, ... (5 entities in total)
Functional Keywords	transferase, atp-binding, cell cycle, cell division, mitosis, nucleotide-binding, nucleus
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	36394.54
Authors	Bertrand, J.A.,Bossi, R.T. (deposition date: 2011-02-18, release date: 2011-04-06, Last modification date: 2019-04-03)
Primary citation	Beria, I.,Bossi, R.T.,Brasca, M.G.,Caruso, M.,Ceccarelli, W.,Fachin, G.,Fasolini, M.,Forte, B.,Fiorentini, F.,Pesenti, E.,Pezzetta, D.,Posteri, H.,Scolaro, A.,Depaolini, S.R.,Valsasina, B. Nms-P937, a 4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline Derivative as Potent and Selective Polo-Like Kinase 1 Inhibitor. Bioorg.Med.Chem.Lett., 21:2969-, 2011 Cited by PubMed: 21470862 DOI: 10.1016/J.BMCL.2011.03.054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation