2Y8L

Structure of the regulatory fragment of mammalian aMPK in complex with two ADP

Summary for 2Y8L

Related2F15 2V8Q 2V92 2YA3 2Y94 2V9J 2Y8Q
Descriptor5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ... (6 entities in total)
Functional Keywordstransferase, nucleotide-binding, serine/threonine-protein kinase
Biological sourceRATTUS NORVEGICUS (NORWAY RAT)
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Cellular locationCytoplasm (By similarity) P54645
Total number of polymer chains3
Total molecular weight68163.35
Authors
Primary citation
Xiao, B.,Sanders, M.J.,Underwood, E.,Heath, R.,Mayer, F.,Carmena, D.,Jing, C.,Walker, P.A.,Eccleston, J.F.,Haire, L.F.,Saiu, P.,Howell, S.A.,Aasland, R.,Martin, S.R.,Carling, D.,Gamblin, S.J.
Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472:230-, 2011
PubMed: 21399626 (PDB entries with the same primary citation)
DOI: 10.1038/NATURE09932
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers60.6%8.4%12.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report