2Y6S

Structure of an Ebolavirus-protective antibody in complex with its mucin-domain linear epitope

2Y6S の概要

• エントリーDOI: 10.2210/pdb2y6s/pdb
• 分子名称: LIGHT CHAIN, HEAVY CHAIN, ENVELOPE GLYCOPROTEIN, ... (4 entities in total)
• 機能のキーワード: immune system-viral protein complex, immune system/viral protein
• 由来する生物種: MUS MUSCULUS (HOUSE MOUSE); 詳細
• 細胞内の位置: GP2: Virion membrane; Single-pass type I membrane protein (By similarity). GP1: Virion membrane; Peripheral membrane protein (By similarity). GP2-delta: Secreted (By similarity): 2Y6S
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 96343.22

構造登録者

Olal, D.O.,Kuehne, A.,Lee, J.E.,Bale, S.,Dye, J.M.,Saphire, E.O. (登録日: 2011-01-25, 公開日: 2012-01-11, 最終更新日: 2024-10-23)

主引用文献

Olal, D.O.,Kuehne, A.,Bale, S.,Halfmann, P.,Hashiguchi, T.,Fusco, M.L.,Lee, J.E.,King, L.B.,Kawaoka, Y.,Dye, J.M.,Saphire, E.O.
Structure of an Ebola Virus-Protective Antibody in Complex with its Mucin-Domain Linear Epitope.
J.Virol., 86:2809-, 2012

PubMed Abstract: Antibody 14G7 is protective against lethal Ebola virus challenge and recognizes a distinct linear epitope in the prominent mucin-like domain of the Ebola virus glycoprotein GP. The structure of 14G7 in complex with its linear peptide epitope has now been determined to 2.8 Å. The structure shows that this GP sequence forms a tandem β-hairpin structure that binds deeply into a cleft in the antibody-combining site. A key threonine at the apex of one turn is critical for antibody interaction and is conserved among all Ebola viruses. This work provides further insight into the mechanism of protection by antibodies that target the protruding, highly accessible mucin-like domain of Ebola virus and the structural framework for understanding and characterizing candidate immunotherapeutics.

PubMed: 22171276
DOI: 10.1128/JVI.05549-11

実験手法

X-RAY DIFFRACTION (2.8 Å)