2Y1X

CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR

Summary for 2Y1X

Entry DOI	10.2210/pdb2y1x/pdb
Related	2Y1W
Descriptor	HISTONE-ARGININE METHYLTRANSFERASE CARM1, S-ADENOSYL-L-HOMOCYSTEINE, N-(3-{5-[5-(1H-INDOL-4-YL)-1,3,4-OXADIAZOL-2-YL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL}BENZYL)-L-ALANINAMIDE, ... (5 entities in total)
Functional Keywords	histone modification, transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: Q86X55
Total number of polymer chains	4
Total formula weight	161588.98
Authors	Sack, J.S.,Thieffine, S.,Bandiera, T.,Fasolini, M.,Duke, G.J.,Jayaraman, L.,Kish, K.F.,Klei, H.E.,Purandare, A.V.,Rosettani, P.,Troiani, S.,Xie, D.,Bertrand, J.A. (deposition date: 2010-12-10, release date: 2011-03-23, Last modification date: 2011-07-13)
Primary citation	Sack, J.S.,Thieffine, S.,Bandiera, T.,Fasolini, M.,Duke, G.J.,Jayaraman, L.,Kish, K.F.,Klei, H.E.,Purandare, A.V.,Rosettani, P.,Troiani, S.,Xie, D.,Bertrand, J.A. Structural Basis for Carm1 Inhibition by Indole and Pyrazole Inhibitors Biochem.J., 436:331-, 2011 Cited by PubMed: 21410432 DOI: 10.1042/BJ20102161 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation