2Y1X
CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | HISTONE-ARGININE METHYLTRANSFERASE CARM1 | polymer | 348 | 39479.9 | 4 | UniProt (Q86X55) Pfam (PF06325) Pfam (PF22528) | HOMO SAPIENS (HUMAN) | CARM1, COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE 1, PROTEIN ARGININE N-METHYLTRANSFERASE 4 |
| 2 | E, H, K, N (A, B, C, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 3 | F, I, L, O (A, B, C, D) | N-(3-{5-[5-(1H-INDOL-4-YL)-1,3,4-OXADIAZOL-2-YL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL}BENZYL)-L-ALANINAMIDE | non-polymer | 497.5 | 4 | Chemie (845) | |||
| 4 | G, J, M, P (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) PubChem (312) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 460 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 157919.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3669.3 | |
| All* | Total formula weight | 161589.0 |
