2Y1X
CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | HISTONE-ARGININE METHYLTRANSFERASE CARM1 | polymer | 348 | 39479.9 | 4 | UniProt (Q86X55) Pfam (PF06325) Pfam (PF22528) | HOMO SAPIENS (HUMAN) | CARM1, COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE 1, PROTEIN ARGININE N-METHYLTRANSFERASE 4 |
| 2 | E, H, K, N (A, B, C, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
| 3 | F, I, L, O (A, B, C, D) | N-(3-{5-[5-(1H-INDOL-4-YL)-1,3,4-OXADIAZOL-2-YL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL}BENZYL)-L-ALANINAMIDE | non-polymer | 497.5 | 4 | Chemie (845) | |||
| 4 | G, J, M, P (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 460 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 157919.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3669.3 | |
| All* | Total formula weight | 161589.0 |
