2Y1X
CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR
Summary for 2Y1X
Entry DOI | 10.2210/pdb2y1x/pdb |
Related | 2Y1W |
Descriptor | HISTONE-ARGININE METHYLTRANSFERASE CARM1, S-ADENOSYL-L-HOMOCYSTEINE, N-(3-{5-[5-(1H-INDOL-4-YL)-1,3,4-OXADIAZOL-2-YL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL}BENZYL)-L-ALANINAMIDE, ... (5 entities in total) |
Functional Keywords | histone modification, transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: Q86X55 |
Total number of polymer chains | 4 |
Total formula weight | 161588.98 |
Authors | Sack, J.S.,Thieffine, S.,Bandiera, T.,Fasolini, M.,Duke, G.J.,Jayaraman, L.,Kish, K.F.,Klei, H.E.,Purandare, A.V.,Rosettani, P.,Troiani, S.,Xie, D.,Bertrand, J.A. (deposition date: 2010-12-10, release date: 2011-03-23, Last modification date: 2024-05-01) |
Primary citation | Sack, J.S.,Thieffine, S.,Bandiera, T.,Fasolini, M.,Duke, G.J.,Jayaraman, L.,Kish, K.F.,Klei, H.E.,Purandare, A.V.,Rosettani, P.,Troiani, S.,Xie, D.,Bertrand, J.A. Structural Basis for Carm1 Inhibition by Indole and Pyrazole Inhibitors Biochem.J., 436:331-, 2011 Cited by PubMed: 21410432DOI: 10.1042/BJ20102161 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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