2XYA

Non-covalent inhibtors of rhinovirus 3C protease.

Summary for 2XYA

Entry DOI	10.2210/pdb2xya/pdb
Related	1A3R 1CQQ 1FPN 1V9U 2HRV
Descriptor	PICORNAIN 3C, 2-PHENYLQUINOLIN-4-OL (3 entities in total)
Functional Keywords	hydrolase, cysteine protease
Biological source	HUMAN RHINOVIRUS SP.
Cellular location	Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P04936
Total number of polymer chains	1
Total formula weight	20347.05
Authors	Petersen, J.,Edman, K.,Edfeldt, F.,Johansson, C. (deposition date: 2010-11-16, release date: 2011-04-27, Last modification date: 2024-05-08)
Primary citation	Baxter, A.,Chambers, M.,Edfeldt, F.,Edman, K.,Freeman, A.,Johansson, C.,King, S.,Morley, A.,Petersen, J.,Rawlins, P.,Spadola, L.,Thong, B.,Poel, H.V.,Williams, N. Non-Covalent Inhibitors of Rhinovirus 3C Protease. Bioorg.Med.Chem.Lett., 21:777-, 2011 Cited by PubMed: 21183345 DOI: 10.1016/J.BMCL.2010.11.110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation