2XYA

Non-covalent inhibtors of rhinovirus 3C protease.

2XYA の概要

• エントリーDOI: 10.2210/pdb2xya/pdb
• 関連するPDBエントリー: 1A3R 1CQQ 1FPN 1V9U 2HRV
• 分子名称: PICORNAIN 3C, 2-PHENYLQUINOLIN-4-OL (3 entities in total)
• 機能のキーワード: hydrolase, cysteine protease
• 由来する生物種: HUMAN RHINOVIRUS SP.
• 細胞内の位置: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P04936
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20347.05

構造登録者

Petersen, J.,Edman, K.,Edfeldt, F.,Johansson, C. (登録日: 2010-11-16, 公開日: 2011-04-27, 最終更新日: 2024-05-08)

• 主引用文献: Baxter, A.,Chambers, M.,Edfeldt, F.,Edman, K.,Freeman, A.,Johansson, C.,King, S.,Morley, A.,Petersen, J.,Rawlins, P.,Spadola, L.,Thong, B.,Poel, H.V.,Williams, N.; Non-Covalent Inhibitors of Rhinovirus 3C Protease.; Bioorg.Med.Chem.Lett., 21:777-, 2011; PubMed: 21183345; DOI: 10.1016/J.BMCL.2010.11.110

実験手法

X-RAY DIFFRACTION (2.4 Å)