2XWD

X-RAY STRUCTURE OF ACID-BETA-GLUCOSIDASE WITH 5N,6O-(N'-(N-OCTYL)IMINO)NOJIRIMYCIN IN THE ACTIVE SITE

2XWD の概要

• エントリーDOI: 10.2210/pdb2xwd/pdb
• 関連するPDBエントリー: 1OGS 1Y7V 2F61 2J25 2V3D 2V3E 2V3F 2WCG 2WKL 2XWE
• 分子名称: GLUCOSYLCERAMIDASE, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: glucocerebrosidase, hydrolase, gaucher disease, sphingolipid metabolism
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116237.35

構造登録者

Brumshtein, B.,Aguilar-Moncayo, M.,Benito, J.M.,Ortiz Mellet, C.,Garcia Fernandez, J.M.,Silman, I.,Shaaltiel, Y.,Sussman, J.L.,Futerman, A.H. (登録日: 2010-11-01, 公開日: 2011-09-14, 最終更新日: 2023-12-20)

• 主引用文献: Brumshtein, B.,Aguilar-Moncayo, M.,Benito, J.M.,Garcia Fernandez, J.M.,Silman, I.,Shaaltiel, Y.,Aviezer, D.,Sussman, J.L.,Futerman, A.H.,Ortiz Mellet, C.; Cyclodextrin-Mediated Crystallization of Acid Beta-Glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues.; Org.Biomol.Chem., 9:4160-, 2011; PubMed: 21483943; DOI: 10.1039/C1OB05200D

実験手法

X-RAY DIFFRACTION (2.66 Å)