2XRA

crystal structure of the HK20 Fab in complex with a gp41 mimetic 5- Helix

Summary for 2XRA

• Entry DOI: 10.2210/pdb2xra/pdb
• Related: 1AIK 1DF4 1DF5 1DLB 1G9M 1GC1 1GZL 1K33 1K34 1MZI 1OPN 1OPT 1OPW 1RZJ 2CMR
• Descriptor: TRANSMEMBRANE PROTEIN GP41, HK20, HUMAN MONOCLONAL ANTIBODY HEAVY CHAIN, HK20, HUMAN MONOCLONAL ANTIBODY LIGHT CHAIN, ... (4 entities in total)
• Functional Keywords: immune system, antibody, monoclonal cells, neutralization tests
• Biological source: SYNTHETIC CONSTRUCT; More
• Cellular location: Surface protein gp120: Virion membrane ; Peripheral membrane protein . Transmembrane protein gp41: Virion membrane ; Single-pass type I membrane protein : P04578
• Total number of polymer chains: 3
• Total formula weight: 72961.45

Authors

Sabin, C.,Corti, D.,Buzon, V.,Seaman, M.S.,Lutje Hulsik, D.,Hinz, A.,Vanzetta, F.,Agatic, G.,Silacci, C.,Langedijk, J.P.M.,Mainetti, L.,Scarlatti, G.,Sallusto, F.,Weiss, R.,Lanzavecchia, A.,Weissenhorn, W. (deposition date: 2010-09-13, release date: 2010-12-15, Last modification date: 2023-12-20)

• Primary citation: Sabin, C.,Corti, D.,Buzon, V.,Seaman, M.S.,Lutje Hulsik, D.,Hinz, A.,Vanzetta, F.,Agatic, G.,Silacci, C.,Mainetti, L.,Scarlatti, G.,Sallusto, F.,Weiss, R.,Lanzavecchia, A.,Weissenhorn, W.; Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41.; PLoS Pathog., 6:e1001195-e1001195, 2010; PubMed: 21124990; DOI: 10.1371/journal.ppat.1001195

Experimental method

X-RAY DIFFRACTION (2.3 Å)