2XQZ

Neutron structure of the perdeuterated Toho-1 R274N R276N double mutant beta-lactamase

Summary for 2XQZ

Entry DOI	10.2210/pdb2xqz/pdb
Related	1BZA 1IYO 1IYP 1IYQ 1IYS 1WE4 2WYX 2XR0
Descriptor	BETA-LACTAMSE TOHO-1 (2 entities in total)
Functional Keywords	hydrolase, extended-spectrum beta-lactamases (esbls), ctx-m-type esbls
Biological source	ESCHERICHIA COLI
Total number of polymer chains	1
Total formula weight	27990.61
Authors	Tomanicek, S.J.,Wang, K.K.,Weiss, K.L.,Blakeley, M.P.,Cooper, J.,Chen, Y.,Coates, L. (deposition date: 2010-09-08, release date: 2010-12-22, Last modification date: 2018-01-31)
Primary citation	Tomanicek, S.J.,Wang, K.K.,Weiss, K.L.,Blakeley, M.P.,Cooper, J.,Chen, Y.,Coates, L. The Active Site Protonation States of Perdeuterated Toho-1 Beta-Lactamase Determined by Neutron Diffraction Support a Role for Glu166 as the General Base in Acylation. FEBS Lett., 585:364-, 2011 Cited by PubMed: 21168411 DOI: 10.1016/J.FEBSLET.2010.12.017 PDB entries with the same primary citation
Experimental method	NEUTRON DIFFRACTION (2.1 Å)

Structure validation