2XPC

Second-generation sulfonamide inhibitors of MurD: Activity optimisation with conformationally rigid analogues of D-glutamic acid

Summary for 2XPC

Entry DOI	10.2210/pdb2xpc/pdb
Descriptor	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, (1R,3R,4S)-4-[({6-[(4-CYANO-2-FLUOROBENZYL)OXY]NAPHTHALEN-2-YL}SULFONYL)AMINO]CYCLOHEXANE-1,3-DICARBOXYLIC ACID, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	ligase, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, ligase synthesis
Biological source	ESCHERICHIA COLI
Cellular location	Cytoplasm : Q8X9Y9
Total number of polymer chains	1
Total formula weight	48338.12
Authors	Sosic, I.,Barreteau, H.,Simcic, M.,Sink, R.,Cesar, J.,Golic-Grdadolnik, S.,Contreras-Martel, C.,Dessen, A.,Amoroso, A.,Joris, B.,Blanot, D.,Gobec, S. (deposition date: 2010-08-26, release date: 2011-05-18, Last modification date: 2023-12-20)
Primary citation	Sosi, I.,Barreteau, H.,Sim, M.,Sink, R.,Cesar, J.,Zega, A.,Grdadolnik, S.G.,Contreras-Martel, C.,Dessen, A.,Amoroso, A.,Joris, B.,Blanot, D.,Gobec, S. Second-Generation Sulfonamide Inhibitors of D- Glutamic Acid-Adding Enzyme: Activity Optimisation with Conformationally Rigid Analogues of D- Glutamic Acid. Eur.J.Med.Chem, 46:2880-, 2011 Cited by PubMed: 21524830 DOI: 10.1016/J.EJMECH.2011.04.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49 Å)

Structure validation