2XHD
Crystal structure of N-((2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H- inden-2-yl)-2-propanesulfonamide in complex with the ligand binding domain of the human GluA2 receptor
Summary for 2XHD
Entry DOI | 10.2210/pdb2xhd/pdb |
Related | 2WJW 2WJX |
Descriptor | GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, SULFATE ION, ... (5 entities in total) |
Functional Keywords | transport protein, ion channel |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Multi-pass membrane protein: P42262 |
Total number of polymer chains | 2 |
Total formula weight | 59664.61 |
Authors | Ward, S.E.,Harries, M.,Aldegheri, L.,Andreotti, D.,Ballantine, S.,Bax, B.D.,Harris, A.J.,Harker, A.J.,Lund, J.,Melarange, R.,Mingardi, A.,Mookherjee, C.,Mosley, J.,Neve, M.,Oliosi, B.,Profeta, R.,Smith, K.J.,Smith, P.W.,Spada, S.,Thewlis, K.M.,Yusaf, S.P. (deposition date: 2010-06-14, release date: 2010-07-21, Last modification date: 2011-07-13) |
Primary citation | Ward, S.E.,Harries, M.,Aldegheri, L.,Andreotti, D.,Ballantine, S.,Bax, B.D.,Harris, A.J.,Harker, A.J.,Lund, J.,Melarange, R.,Mingardi, A.,Mookherjee, C.,Mosley, J.,Neve, M.,Oliosi, B.,Profeta, R.,Smith, K.J.,Smith, P.W.,Spada, S.,Thewlis, K.M.,Yusaf, S.P. Discovery of N-[(2S)-5-(6-Fluoro-3-Pyridinyl)-2,3-Dihydro-1H-Inden-2-Yl]-2-Propanesulfonamide, a Novel Clinical Ampa Receptor Positive Modulator. J.Med.Chem., 53:5801-, 2010 Cited by PubMed: 20614889DOI: 10.1021/JM1005429 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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