2XHB

Crystal structure of DNA polymerase from Thermococcus gorgonarius in complex with hypoxanthine-containing DNA

Summary for 2XHB

• Entry DOI: 10.2210/pdb2xhb/pdb
• Related: 1TGO 1WN7 2VWJ 2VWK
• Descriptor: DNA POLYMERASE, HYPOXANTHINE-CONTAINING DNA, 5'-D(*AP*AP*AP*AP*AP*AP*AP*AP*A)-3', ... (5 entities in total)
• Functional Keywords: transferase-dna complex, replication, exonuclease, dna damage, exo minus, transferase/dna
• Biological source: THERMOCOCCUS GORGONARIUS
• Total number of polymer chains: 3
• Total formula weight: 101327.66

Authors

Killelea, T.,Ghosh, S.,Tan, S.S.,Heslop, P.,Firbank, S.J.,Kool, E.T.,Connolly, B.A. (deposition date: 2010-06-14, release date: 2010-07-21, Last modification date: 2023-12-20)

• Primary citation: Killelea, T.,Ghosh, S.,Tan, S.S.,Heslop, P.,Firbank, S.J.,Kool, E.T.,Connolly, B.A.; Probing the Interaction of Archaeal DNA Polymerases with Deaminated Bases Using X-Ray Crystallography and Non-Hydrogen Bonding Isosteric Base Analogues.; Biochemistry, 49:5772-, 2010; PubMed: 20527806; DOI: 10.1021/BI100421R

Experimental method

X-RAY DIFFRACTION (2.72 Å)